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Adaptive Clinical Trials |
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ClinAsia Labs is very well geared up to avoid the late stage disorders occurring in a clinical trial due to small over look or miscalculation in the phase 2 settings of a clinical trial as it is not possible counter the late stage disorders taking into consideration the time, money and efforts spent on the study.
ClinAsia Labs with its expertise and experience proposes adaptive clinical trial designs are more effective than traditional designs in cases where there is uncertainty surrounding the dose, effect size and variability, clinical endpoint or patient populations as ClinAsia Labs while closely working with its clients observes that Major Pharma companies today are implementing adaptive trials to improve dose-finding in the Phase 2 setting of a clinical trial. The use of adaptive clinical trials will increase across the industry over the next 2-3 years.
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ClinAsia Labs believes its adaptive clinical trials design services are very promising as they aim to advance a decision to the Sponsor at the very early stage in a clinical trial about the error or disorder which may be likely to occur in the future course of study. It gives the sponsor an option to continue, rectify or terminate the study along with the first hand information of the possible error in the latter stage of clinical trials.
ClinAsia Labs designs and conducts the studies required by our clients keeping an eye on future after the completion of the study as well. ClinAsia Labs always thinks on the lines of the maximum benefit to our clients and see them create the miracles out of their medicine through ClinAsia Labs. We at ClinAsia Labs are concerned about the manufacturing facilities of our clients after the completion of the study and accordingly design the study to give them the maximum advantage. ClinAsia Labs fine-tunes the study to their requirement and convenience. |
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ClinAsia Labs Adaptive clinical trial design is basically a framework which allows in faster completion of a clinical trial and provides the information on latter possible disorders with the careful analysis of the present available data. ClinAsia Labs ensures that cleaned data is available live for accurate analysis by employing the following as a part of its Adaptive trial design framework right from design, analysis and execution. |
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- Adjusting Randomization Probabilities
- Linking Randomization Systems and Drug Supplies Tracking
- Bringing live information from various sources (EDC) to one real time system for detailed analysis
- Efficient Electronic Data Capture capabilities for the entire study for future reference
- Efficient Statistical Analysis Capabilities
- Flexible access to review and analyze the data as and when required
- Easy access and reporting
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Service Offerings |
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Adaptive Clinical Trials Design:
ClinAsia Labs utilizes the expertise of its experts to help sponsor with the simulation designs and obtain approval for a trail that directly saves on money and time. The following are few services as a part of ClinAsia Labs Adaptive Clinical Trials Design.
- Combined design of Phase II learning study with a Phase III confirming study
- Making complex Phase IIIb trial more effective
- Design of a combined proof of concept and Phase IIa dose finding trial
- Web based Phase II dose response trial
- Use of Bayesian and Frequentist approach
- Design and Analysis of covariate-adaptive trials
Adaptive Clinical Trials Implementation:
ClinAsia Labs develops a customized and centralized integrated approach for any of your adaptive trial needs including:
- Logistics and supply management planning
- Inserting an adaptive algorithm in to IVRS
- Integrating IVRS, Simulation tool, Drug Supply forecasting, Patient Profiles and EDC
- Creation of Interim reports containing trial data tables and simulation results.
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